Chenn Lab Research

Welcome to the Chenn Lab!

Our major research interest is understanding the factors that control cell proliferation and differentiation in the developing mammalian central nervous system. The ongoing research of the lab seeks to understand the function and control of these pathways in both normal and tumor cells. The identification and better understanding of these key pathways can lead to improved diagnostic tools and novel drug targets in brain cancer. See our Research page for details. We are a member of the Northwestern Brain Tumor Institute and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

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Our latest publications!

Mutch CA, Schulte JD, Olson E, Chenn A.
Beta-catenin signaling negatively regulates intermediate progenitor population numbers in the developing cortex.
PLoS One. 2010 Aug 25;5(8). pii: e12376.PMID: 20811503 [PubMed - in process]Free PMC Article
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Zhang, J., Woodhead, G. J., Swaminathan, S. K., Noles, S. R., McQuinn, E. R., Pisarek, A. J., Stocker, A. M., Mutch, C. A., Funatsu, N., and Chenn, A. (2010).
Cortical Neural Precursors Inhibit Their Own Differentiation via N-Cadherin Maintenance of [beta]-Catenin Signaling.
Developmental Cell 18, 472-479.

Mutch CA, Funatsu N, Monuki ES, Chenn A.
Beta-catenin signaling levels in progenitors influence the laminar cell fates of projection neurons.
J Neurosci. 2009 Oct 28;29(43):13710-9.

Stocker A. and Chenn, A.Focal Reduction of aE-catenin Causes Premature Differentiation and Reduction of ß-catenin Signaling During Cortical Development.
Dev Biol, Vol. 328, 1

Chenn A.
A top-NOTCH way to make astrocytes
Dev Cell. 2009 Feb;16(2):158-9.
publisher site
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Chenn A.
Wnt/beta-catenin signaling in cerebral cortical development
Organogenesis. 2008 Apr;4(2):76-80
Free Article at PMC