Welcome to the Chenn Lab!
Our major research interest is understanding the factors that control cell proliferation and differentiation in the developing mammalian central nervous system. See our Research page for details.
Latest News
Congratulations to the Stepanie Noles, Ph. D.! (Center)
Congratulations to the newly-minted Gregory Woodhead, Ph. D.!
We were recently awarded a grant from the March of Dimes Research Program for our research studying "Beta Catenin Regulation of Neuronal Production during Development."
The long term goal of this research is to learn how normal neural stem/progenitor cells regulate their self-renewal. This research aims to provide a mechanistic understanding of how to protect neural stem/progenitor cells from environmental factors that may lead to developmental problems and may suggest potential protective or interventional approaches for individuals who may present with existing clinical conditions.
Special thanks to Greg and Sruthi for providing critical preliminary data for this grant application.
Our latest publications!
Wrobel, C. N., Mutch, C. A., Swaminathan, S. K., Taketo, M. M.,
and Chenn, A. Persistent expression of stabilized beta-catenin
delays maturation of radial glial cells into intermediate progenitors.
Dev Biol. 2007 Sep 15;309(2):285-97. Jul 24; [Epub ahead of print]
PMID: 17706960 [PubMed - in process]
medline
Noles, S. R. and Chenn, A.
Cadherin inhibition of beta-catenin signaling regulates the proliferation
and differentiation of neural precursor cells.
Mol Cell Neurosci. 2007 Aug;35(4):549-58. Epub 2007 May 8.
PMID: 17553695 [PubMed - in process](2007)
medline
Woodhead, G. J., Mutch, C. A., Olson, E. C., and
Chenn, A.
Cell-Autonomous beta-Catenin Signaling Regulates Cortical Precursor Proliferation.
J Neurosci. 2006 Nov 29;26(48):12620-30.
PMID: 17135424 [PubMed - indexed for MEDLINE]
medline
(featured
in This
Week in The Journal)
Stocker A.M. and Chenn, A.
Differential expression of alpha-E-catenin and alpha-N-catenin
in the developing cerebral cortex.
Brain Res. 2006 Jan 31; [Epub ahead of print]
PMID: 16457793 [PubMed - as supplied by publisher]
medline
Our research is made possible by generous funding sources
The American Cancer Society, Illinois Division
The National Institute of Neurological Disorders and Stroke, National Institutes of Health
The Sontag Foundation Distinguished Scholar Award